Open AccessLeptin and Adipose Tissue Maldistribution in HIV-Infected Male Patients With Predominant Fat Loss Treated With Antiretroviral Therapy
Author(s) -
Vicente Estrada,
Manuel Serrano-Rı́os,
María Teresa Martínez Larrad,
Noemí González Pérez de Villar,
Amparo González López,
María J. Téllez,
Cristina Fernández
Publication year - 2002
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200201010-00004
Subject(s) - medicine , insulin resistance , endocrinology , lipodystrophy , adipose tissue , leptin , insulin , hypertriglyceridemia , homeostatic model assessment , glucose homeostasis , triglyceride , biology , cholesterol , obesity , viral load , antiretroviral therapy , human immunodeficiency virus (hiv) , immunology
Metabolic disturbances and fat maldistribution are main features of the antiretroviral-related lipodystrophy syndrome (LDS). Different phenotypes of fat distribution abnormalities can be observed: fat loss, fat accumulation, or a mixed pattern. In patients with predominant loss of fat, the roles of leptin, lipids, and glucose homeostasis disturbances have not yet been clearly established.