Open AccessZidovudine Genotypic Resistance in HIV-1–Infected Newborns in the French Perinatal Cohort
Author(s) -
Bernard Masquelier,
MarieLaure Chaix,
Marianne Burgard,
Jérôme Lechenadec,
Anne Doussin,
François Simon,
J. Cottalorda,
Jacques Izopet,
Catherine Tamalet,
Danielle Douard,
Hervé Fleury,
Marie-Jeanne Mayaux,
Stéphane Blanche,
Christine Rouzioux
Publication year - 2001
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200106010-00001
Subject(s) - zidovudine , virology , genotype , sida , cohort , transmission (telecommunications) , context (archaeology) , drug resistance , lentivirus , cohort study , medicine , biology , human immunodeficiency virus (hiv) , viral disease , genetics , gene , paleontology , electrical engineering , engineering
A retrospective study was set up to investigate the frequency of zidovudine (ZDV)-resistant HIV-1 in infected newborns after ZDV prophylaxis in the French Perinatal Cohort study. Nucleotide sequence analysis was carried out from 34 infants' isolates and 18 maternal plasma samples. Mutations related to ZDV resistance were found in the HIV-1 reverse transcriptase in 7 of 34 children (20%). Evidence of mother-child transmission of ZDV-resistant HIV-1 was found in 4 cases. Phylogenetic analysis showed that 14 of 34 HIV-1 isolates from the infants belonged to non-B subtypes. The presence of ZDV resistance-encoding mutations in the newborn isolates was associated with a longer total duration of exposure to ZDV. In a context of a wide HIV-1 variability, ZDV resistance can be one of the factors contributing to mother-child transmission.