Open AccessHIV Viral Load in Thai Men and Women With Subtype E Infections
Author(s) -
Rapee Trichavaroj,
Mark S. de Souza,
Puangmalee Buapunth,
Lauri E. Markowitz,
Suchitra Sukwit,
Sorachai Nitayaphan,
Arthur E. Brown
Publication year - 2001
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200104010-00009
Subject(s) - viral load , human immunodeficiency virus (hiv) , rna , medicine , virology , immunology , lentivirus , viral disease , biology , genetics , gene
The assessment of potential "breakthrough infections" in HIV vaccine trials requires knowledge of viral load in unvaccinated persons. Therefore, HIV-1 RNA was quantitated in plasma from Thai adults with subtype E infections. RNA was detectable (> or =500 copies/ml) in 93% of 255 specimens, with a mean (standard deviation) value of 4.09 (0.88) log copies/ml. The concentration of RNA was directly related to the presence of AIDS-defining illnesses, inversely related to CD4 count, and independent of gender after adjustment for CD4 count.