Open AccessPrevalence and Correlates of Anemia in a Large Cohort of HIV-Infected Women: Women's Interagency HIV Study
Author(s) -
Alexandra M. Levine,
Kiros Berhane,
Lena Masri-Lavine,
Maria Lynn Sanchez,
Mary Young,
Michael Augenbraun,
Mardge H. Cohen,
Kathryn Anastos,
Margaret Newman,
Stephen J. Gange,
Heather Watts
Publication year - 2001
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200101010-00004
Subject(s) - medicine , anemia , mean corpuscular volume , multicenter aids cohort study , asymptomatic , prospective cohort study , cohort study , logistic regression , cohort , immunology , human immunodeficiency virus (hiv) , hemoglobin , sida , viral disease
Anemia is a common manifestation of HIV infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. We performed a cross-sectional study nested within a multicenter prospective cohort study to describe the prevalence of anemia in 2056 HIV-infected and 569 HIV-negative women as well as to define the demographic, clinical, immunologic, and virologic correlates of anemia among HIV-infected women. A total of 37% of HIV-positive women and 17% of HIV-negative women had hemoglobin levels < 12 g/dl (p < .001). Factors associated with anemia in HIV-positive and HIV-negative women included mean corpuscular volume (MCV) < 80 fl (p < .001) and black race (p < .001). Among HIV-infected women, multivariate logistic analyses revealed that African American race (p < .0001), MCV < 80 fl (p < .0001), CD4 count < 200 per microliter (p <.0001), higher HIV RNA in plasma (p = .02), current use of ZDV (p = .01), and history of clinical AIDS (p = .004) were all independent predictors of anemia. These data indicate that worsening parameters of HIV disease are associated with anemia among HIV-infected women. Black women and women with low MCV values are at increased risk for anemia independent of HIV status.