Open AccessBacteremia in HIV-Infected Patients: Short-Term Predictors of Mortality
Author(s) -
C Omeñaca,
Glenn S. Turett,
Robert Yarrish,
María Teresa Vidán Astiz,
Rong-Dih Lin,
Jay Ward Kislak,
Joseph Cadden
Publication year - 1999
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-199910010-00007
Subject(s) - bacteremia , medicine , septic shock , cohort , sepsis , mortality rate , malignancy , cohort study , human immunodeficiency virus (hiv) , surgery , immunology , antibiotics , biology , microbiology and biotechnology
To identify characteristics associated with mortality in HIV-infected patients with bacteremia, 88 bacteremic episodes in 80 HIV-infected patients were prospectively identified over a 5-month period and observed for 30 days. Demographic, clinical, laboratory, and radiologic data were collected. Mean and median age was 41 years. Most study subjects were homosexual men. Median CD4 count was 20 cells/mm3. Gram-positive organisms predominated (65%). The most common source of bacteremia was intravascular catheters (45%). Overall mortality was 30%. A history of malignancy, three or more opportunistic infections, shock, low hemoglobin, source of bacteremia other than an intravascular catheter, resistance to therapy, and a second bacteremic episode during the study period, were all found to be independent predictors of mortality. In this cohort of HIV-infected patients, most of whom were severely immunosuppressed, several factors were found to be significantly and independently associated with mortality.