Open AccessOsteogenic Sarcoma Associated With Diamond???Blackfan Anemia: A Report From the Diamond???Blackfan Anemia Registry
Author(s) -
Jeffrey M. Lipton,
Noah Federman,
Youssef Khabbaze,
Cindy L. Schwartz,
Lee Hilliard,
Joseph I. Clark,
Adrianna Vlachos
Publication year - 2001
Publication title -
the american journal of pediatric hematology/oncology
Language(s) - English
Resource type - Journals
eISSN - 2331-4532
pISSN - 0192-8562
DOI - 10.1097/00043426-200101000-00009
Subject(s) - medicine , diamond–blackfan anemia , sarcoma , pediatrics , anemia , fanconi anemia , pathology , ribosome , rna , biochemistry , chemistry , dna repair , gene
Diamond-Blackfan anemia (DBA) is a congenital pure red cell aplasia, usually presenting in infancy or early childhood. A review of the literature strongly supports a predisposition to hematopoietic malignancy. Recently, solid tumors have been reported, some attributable to hemosiderosis and/or androgen therapy. Two cases of osteogenic sarcoma have also been documented. An analysis from the Diamond-Blackfan Anemia Registry was performed to evaluate the cancer risk in patients with DBA.