Open AccessPancreatic autoantibodies in Crohn's disease
Author(s) -
Török Hp,
C Folwaczny
Publication year - 2005
Publication title -
european journal of gastroenterology and hepatology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.881
H-Index - 102
eISSN - 1473-5687
pISSN - 0954-691X
DOI - 10.1097/00042737-200501000-00008
Subject(s) - medicine , disease , autoantibody , crohn's disease , inflammatory bowel disease , immunology , ulcerative colitis , antibody , pathogenesis , clinical phenotype , phenotype , pathology , genetics , gene , biology
Potential implications of antibody markers in Crohn's disease: Diagnostic markers, alone or in conjunction with other antibodies? Delineation of clinical phenotypes? Markers of disease behaviour? Markers of (genetic) susceptibility? Identification of genetically homogenous subgroups? Bridge between basic science and clinic? The exact role of serum antibodies in inflammatory bowel disease remains a matter of ongoing debate. Although a direct implication in the disease pathogenesis is unlikely, their diagnostic potential in cases of an undetermined colitis or in defining clinical phenotypes in Crohn's disease has been shown in several studies. Serum antibodies might also be helpful in predicting the disease behaviour and are thus valuable tools in the choice of medical or surgical therapy.