Open AccessThe natriuretic peptide family
Author(s) -
Masashi Mukoyama,
Akira Sugawara,
Hiroaki Itoh,
Kazuhiro Nakao
Publication year - 1996
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/00041552-199601000-00003
Subject(s) - npr2 , npr1 , natriuretic peptide , atrial natriuretic peptide , receptor , medicine , homeostasis , peptide , peptide hormone , endocrinology , guanylate cyclase , chemistry , biochemistry , heart failure
The natriuretic peptide system is a complicated system comprising at least three endogenous peptides (atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide) and three receptors [the atrial natriuretic peptide-A receptor (guanylyl cyclase A), the atrial natriuretic peptide-B receptor (guanylyl cyclase B) and the clearance receptor]. The accumulated evidence indicates that this system is implicated in the control of blood pressure, body fluid homeostasis and vascular remodelling as cardiac hormone and local regulator.