Open AccessELEVATED SERUM LEVELS OF S-100B REFLECT THE EXTENT OF BRAIN INJURY IN ALCOHOL INTOXICATED PATIENTS AFTER MILD HEAD TRAUMA
Author(s) -
Peter Biberthaler,
Thomas Mussack,
E. Wiedemann,
T Gilg,
Michael Soyka,
Gabi Koller,
K. J. Pfeifer,
Ulrich Linsenmaier,
Wolf Mutschler,
Cornelia Gippner-Steppert,
Marianne Jochum
Publication year - 2001
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/00024382-200116020-00002
Subject(s) - alcohol intoxication , medicine , alcohol , head trauma , head injury , incidence (geometry) , anesthesia , alcoholic intoxication , gastroenterology , surgery , poison control , injury prevention , emergency medicine , chemistry , optics , biochemistry , physics
Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.