Open AccessEFFECT OF DELAYED TREATMENT WITH RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON SURVIVAL AND PLASMA CYTOKINE LEVELS IN A NON-NEUTROPENIC PORCINE MODEL OF PSEUDOMONAS AERUGINOSA SEPSIS
Author(s) -
Jörg Haberstroh,
K. Wiese,
Andrea Geist,
Gülra B. Dursunoglu,
Cornelia Gippner-Steppert,
Marianne Jochum,
Bernd-u. v. Specht
Publication year - 1998
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/00024382-199802000-00009
Subject(s) - sepsis , leukopenia , granulocyte colony stimulating factor , pseudomonas aeruginosa , cytokine , medicine , granulocyte , septic shock , immunology , gastroenterology , biology , chemotherapy , bacteria , genetics
Neutrophils are of great importance for the host's defense against invading organisms. Granulocyte colony-stimulating factor (G-CSF) has been used to augment both the neutrophil number and function, and its prophylactic administration has proved beneficial in animal models of sepsis. However, pretreatment with G-CSF is not practical under clinical conditions. We therefore investigated the effect of recombinant human (rh)G-CSF, administered only after infection, on the survival rate as well as the hemodynamic and cytokine response of the animals.