Open AccessThe impact of cyclosporine dose reduction with or without the addition of rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy
Author(s) -
Rick Saunders,
G R Bicknell,
Michael L. Nicholson
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200303270-00008
Subject(s) - urology , sirius red , medicine , chronic allograft nephropathy , renal function , nephrotoxicity , sirolimus , ciclosporin , nephropathy , creatinine , biopsy , kidney , fibrosis , endocrinology , kidney transplantation , diabetes mellitus
Overexposure to cyclosporine is a risk factor for chronic allograft nephropathy (CAN) and dose reduction has been advocated. The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin, after cyclosporine dose reduction in renal-allograft recipients with CAN.