Open AccessPreconditioning with cyclosporine a or fk506 differentially regulates mitogen-activated protein kinase expression in rat kidneys with ischemia/reperfusion injury12
Author(s) -
Chul Woo Yang,
Hyo Jun Ahn,
Jongwan Jung,
Wan Young Kim,
Can Li,
Bum Soon Choi,
Hyung Wook Kim,
Yong Soo Kim,
In Sung Moon,
Jin Kim,
Byung Kee Bang
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200301150-00004
Subject(s) - mapk/erk pathway , p38 mitogen activated protein kinases , kinase , kidney , ischemia , medicine , reperfusion injury , protein kinase a , immunohistochemistry , pharmacology , mitogen activated protein kinase , endocrinology , chemistry , biochemistry
The signaling pathways of mitogen-activated protein kinases (MAPKs) are important molecular components responsible for ischemia/reperfusion (I/R) injury in the kidneys. Preconditioning with cyclosporine A (CsA) or FK506 reduces subsequent I/R injury. We studied the effect of preconditioning with CsA or FK506 on MAPK expression in ischemic rat kidneys.