Open Access??-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation1
Author(s) -
Stefano Gatti,
Gualtiero Colombo,
Roberto Buffa,
Flavia Turcatti,
Letizia Garofalo,
Nadia Carboni,
Luca Ferla,
L. R. Fassati,
James M. Lipton,
Anna Catania
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200212270-00005
Subject(s) - medicine , transplantation , immunosuppression , reperfusion injury , organ transplantation , hormone , endocrinology , immunology , ischemia
With the increasing need for organ transplantation and the use of "marginal" organs, novel approaches are sought to increase the efficiency and survival of transplanted tissue. We tested the idea that treatment with the anti-inflammatory peptide, alpha-melanocyte-stimulating hormone (alpha-MSH), an endogenous hormone that does not cause marked immunosuppression but does reduce reperfusion injury, may protect allografts and prolong their survival.