Open AccessImmune reconstitution at 6 months following t-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome
Author(s) -
Nicolás Novitzky,
Glenda Mary Davison,
Geoff Hale,
Herman Waldmann
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200212150-00012
Subject(s) - medicine , bone marrow , immunology , transplantation , cd8 , stem cell , progenitor cell , population , haematopoiesis , hematopoietic stem cell transplantation , immune system , t cell , biology , environmental health , genetics
Compared with allogeneic bone marrow, in cytokine mobilized blood stem cell grafts, the number of hematopoietic progenitors and lymphoid cells is higher. Consequently, we compared the immune reconstitution following these two transplant modalities in patients receiving T-cell depleted grafts for hematological malignancies and studied the impact of lymphocyte subset recovery on clinical outcome.