Open AccessT cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients1
Author(s) -
Jessamyn Bagley,
Chaorui Tian,
David H. Sachs,
John Iacomini
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200211270-00019
Subject(s) - bone marrow , cd154 , cd8 , genetic enhancement , immunology , biology , major histocompatibility complex , cd40 , total body irradiation , cytotoxic t cell , microbiology and biotechnology , cancer research , antigen , gene , in vitro , chemotherapy , genetics , cyclophosphamide
In order for gene therapy to attain clinical relevance, efficient engraftment and long-term survival of cells that express transduced genes of interest must be achieved. In this study, we examined the extent to which host T cells affect engraftment of syngeneic bone marrow cells engineered to express a retrovirally transduced allogeneic major histocompatibility complex class-I gene.