Open AccessInduction of tolerance in composite-tissue allografts
Author(s) -
Maria Siemionow,
Turgut Ortak,
Dariusz Iżycki,
Ramadan Öke,
Brian Cunningham,
Rita Prajapati,
James E. Zins
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200211150-00002
Subject(s) - immunosuppression , mixed lymphocyte reaction , immunology , immune tolerance , transplantation , major histocompatibility complex , t cell receptor , medicine , monoclonal antibody , immunocompetence , peripheral tolerance , immune system , t cell , cancer research , biology , antibody
Transplantation of composite-tissue allograft (CTA) such as the human hand recently became a clinical reality. The high risks associated with the use of lifelong immunosuppression have been the prohibiting factor in the routine use of the CTA transplants. In this article, we present a new approach of inducing long-term, donor-specific tolerance to CTAs without recipient preconditioning and need for chronic immunosuppression.