Open AccessApolipoprotein E gene polymorphism alters lipids before pancreas transplantation
Author(s) -
Sajeev Balakrishnan,
Christopher Colling,
Tab Burkman,
Judi Erickson,
Elizabeth Lyden,
Hiralal Maheshwari,
Lynn Mack-Shipman,
James T. Lane,
Jennifer L. Larsen
Publication year - 2002
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200210150-00013
Subject(s) - medicine , dyslipidemia , endocrinology , hyperlipidemia , genotype , transplantation , apolipoprotein e , apolipoprotein b , allele , diabetes mellitus , gene polymorphism , lipid profile , blood lipids , cholesterol , biology , genetics , gene , disease
Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, particularly E2 and E4 alleles, increases the risk of dyslipidemia. Apo E2 has also been found to increase risk of diabetic nephropathy and so may be more prevalent in PTX candidates.