Open AccessOral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD
Author(s) -
HenkJan Schuurman,
Klaus Menninger,
Maxime Audet,
Adrien Kunkler,
Claudine Maurer,
Corinne Vedrine,
Mario Bernhard,
Lorrie Gaschen,
Volker Brinkmann,
Valérie Quesniaux
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200210150-00009
Subject(s) - allotransplantation , creatinine , medicine , kidney , immunosuppression , transplantation , pharmacology , renal function , urology
FTY720 is a novel immunomodulator with a unique mechanism of action, i.e. chemokine-dependent lymphocyte homing into secondary lymphoid organs associated with profound lymphocyte depletion in blood. We investigated its efficacy, either FTY720 alone or together with cyclosporine or the rapamycin derivative rapamycin derivative (RAD), in cynomolgus monkey kidney allotransplantation.