Open AccessDifferential modulation of CD4 and CD8 T-cell roliferation by induction of nitric oxide synthesis in anigen presenting cells1.
Author(s) -
Rosemary A. Hoffman,
Raja S. Mahidhara,
Amanda WolfJohnston,
Lina Lü,
Angus W. Thomson,
Richard L. Simmons
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200209270-00018
Subject(s) - t cell , cd8 , cytotoxic t cell , microbiology and biotechnology , antigen presenting cell , cell growth , chemistry , cytokine , biology , antigen , immunology , immune system , biochemistry , in vitro
On antigenic stimulation, CD4 T cells generally proliferate more readily than CD8 T cells. The purpose of the present experiments was to determine whether nitric oxide (NO) might differentially modulate CD4 vs. CD8 T-cell proliferation.