Open AccessMagnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism.
Author(s) -
Tomio Asai,
Tatsuya Nakatani,
Shinya Yamanaka,
Satoshi Tamada,
Toshifumi Kishimoto,
Koichiro Tashiro,
Takafumi Nakao,
Mitsu Okamura,
Shokei Kim,
Hiroshi Itoh,
Katsuyuki Miura
Publication year - 2002
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200209270-00009
Subject(s) - endocrinology , medicine , fibrosis , glomerulosclerosis , nephropathy , kidney , angiotensin ii , renal function , monocyte , inflammation , nephrotoxicity , pharmacology , chemistry , receptor , proteinuria , diabetes mellitus
We have previously shown that correction of hypomagnesemia by magnesium (Mg) supplementation ameliorates chronic cyclosporine A (CsA) nephropathy via inhibiting gene expression of fibrogenic molecules. Experiments were conducted to further elucidate upstream mechanism of the beneficial effects upon CsA nephrotoxicity.