Open AccessInterleukin-10 modulation of alloreactivity and graft-versus-host reactions.
Author(s) -
Xiao-g Wang,
Claudia Lange,
Ute Schulz,
Lisbet Sviland,
G??nther Eissner,
Kristyna M. Oliver,
Graham Jackson,
Ernst Holler,
Anne M. Dickinson
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200209270-00007
Subject(s) - immunology , cytokine , mixed lymphocyte reaction , cytolysis , in vitro , interleukin , t cell , medicine , biology , cytotoxicity , immune system , biochemistry
The biological properties of interleukin (IL)-10 in tolerance induction and inhibition of alloreactivity have suggested a therapeutic use of this cytokine as an additional or alternative prophylaxis for graft-versus-host disease (GvHD). However, the effects of exogenous IL-10 on GvHD are mainly studied in animal models, and the results remain conflicting. This study aims to demonstrate, for the first time, whether the addition of exogenous IL-10 can reduce the severity of graft-versus-host reactions (GvHR) in humans.