Open AccessIdentification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts1
Author(s) -
Suchitra SumitranHolgersson,
H Wilczek,
Jan Holgersson,
Kalle Söderström
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200207270-00019
Subject(s) - antibody , human leukocyte antigen , kidney transplantation , immunology , humoral immunity , transplantation , major histocompatibility complex , mhc class i , immune system , biology , medicine , antigen
A substantial portion of kidney allografted patients experience early acute rejection episodes and even irreversible rejections in the early posttransplantation period. The presence of HLA alloantibodies before grafting is associated with early immunological complications, but in many patients rejections and graft loss occur even in the absence of such antibodies.