Open AccessImprovement in rejection of human decay accelerating factor transgenic pig-to-primate renal xenografts with administration of rabbit antithymocyte serum1
Author(s) -
Anand Ghanekar,
Ginette Lajoie,
Yigang Luo,
Hongji Yang,
Jihun Choi,
Bertha García,
Edward Cole,
Paul D. Greig,
Mark S. Cattral,
M. James Phillips,
Carl Cardella,
Gary Levy,
Robert Zhong,
David Grant
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200207150-00006
Subject(s) - histopathology , xenotransplantation , immunosuppression , medicine , kidney , cyclophosphamide , transplantation , methylprednisolone , pathology , chemotherapy
Survival in pig-to-baboon kidney xenotransplantation is currently limited by acute humoral xenograft rejection (AHXR). We hypothesized that the administration of rabbit antithymocyte serum (RATS) would delay or prevent AHXR as compared with a cyclophosphamide (CyP)-based immunosuppressive regimen.