Open AccessInducing tolerance to MHC-matched allogeneic islet grafts in Diabetic NOD mice by simultaneous islet and bone marrow transplantation under nonirradiative and nonmyeloablative conditioning therapy
Author(s) -
Tao Wu,
Brett K. LevayYoung,
Neal D. Heuss,
Hakan Sözen,
Nicole Kirchhof,
David E.R. Sutherland,
Bernhard J. Hering,
Zhixin Guo
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200207150-00005
Subject(s) - islet , transplantation , nod mice , medicine , immunology , bone marrow , nod , fludarabine , total body irradiation , type 1 diabetes , cyclophosphamide , diabetes mellitus , endocrinology , chemotherapy
Human type 1 diabetes is associated with defects in the hematopoietic stem cells. Simultaneous donor islet and bone marrow transplantation may be an ideal therapeutic approach for inducing tolerance to islet allogeneic antigens and restoring self-tolerance to islet autoimmune antigens.