Open AccessInvestigation of promoter polymorphisms in the tumor necrosis factor-?? and interleukin-10 genes in liver transplant patients
Author(s) -
Helen Fernandes,
Baburao Koneru,
Neil F. Fernandes,
Meera Hameed,
Marion C. Cohen,
Elizabeth Raveché,
Stanley A. Cohen
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200206270-00006
Subject(s) - promoter , tumor necrosis factor alpha , biology , genotype , cytokine , immunology , liver transplantation , single nucleotide polymorphism , gene , peripheral blood mononuclear cell , interleukin 6 , interleukin , interleukin 10 , microbiology and biotechnology , transplantation , medicine , gene expression , genetics , in vitro
Cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 play significant roles in the inflammatory and immune responses that mediate allograft rejection. The presence of a G-->A polymorphism at position -308 in the promoter region of the TNF-alpha gene increased its transcription 6- to 7-fold. A similar polymorphism at position -1082 of the IL-10 promoter results in decreased production of IL-10 protein. In this study we have determined whether the single nucleotide polymorphisms in the promoter regions of the TNF-alpha and IL-10 genes can predict the outcome of the allograft in liver recipients.