Open AccessAnti-idiotypic antibodies from highly sensitized patients stimulate B cells to produce anti-HLA antibodies
Author(s) -
Nashrudeen Hack,
Sarita Angra,
E. G. Friedman,
T. McKnight,
Carl Cardella
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200206270-00001
Subject(s) - antibody , immunology , antigen , human leukocyte antigen , b cell , in vitro , isoantibodies , transplantation , medicine , chemistry , microbiology and biotechnology , biology , biochemistry
Sustained allosensitization increases waiting time for transplantation and increases the risk of rejection. The purpose of this study is to examine the effect of anti-idiotypic antibodies on B-cell responses and to define their role in alloantibody production.