Open AccessGlomerular targeting of acidic fibroblast growth factor-1 in renal transplanted rats1
Author(s) -
Kurt R. Zinn,
Stacey S. Kelpke,
Kabir M. Akhi,
Liliana Viera,
Tuhin K. Chaudhuri,
John A. Thompson
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200205150-00014
Subject(s) - kidney , fibroblast growth factor , in vivo , transplantation , renal function , medicine , basic fibroblast growth factor , distribution (mathematics) , kidney transplantation , pathology , endocrinology , growth factor , biology , receptor , mathematical analysis , microbiology and biotechnology , mathematics
Acidic fibroblast growth factor (FGF-1) functions as a potent hormonal inducer of wound repair mechanisms in vivo. In addition, the involvement of FGF-1 in a number of pathophysiological conditions, including chronic human renal allograft rejection, has been described. Consequently, there is an increasing need to monitor FGF-1 pharmacokinetics and distribution for both therapeutic and diagnostic opportunities. We now describe in vivo imaging and targeting of FGF-1 in renal transplanted rats.