Open AccessMixed chimerism and immunosuppressive drug withdrawal after hla-mismatched kidney and hematopoietic progenitor transplantation1
Author(s) -
Maria T. Millan,
Judith A. Shizuru,
Petra Hoffmann,
Sussan Dejbakhsh-Jones,
John Scandling,
F. Carl Grumet,
Jane C. Tan,
Oscar Salvatierra,
Richard T. Hoppe,
Samuel Strober
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200205150-00005
Subject(s) - immunology , medicine , bone marrow , progenitor cell , haematopoiesis , prednisone , cd34 , graft versus host disease , human leukocyte antigen , immunosuppression , transplantation , stem cell , antigen , biology , genetics
Rodents and dogs conditioned with total-lymphoid irradiation (TLI), with or without antithymocyte globulin (ATG), have been shown to develop mixed chimerism and immune tolerance without graft-versus-host disease (GVHD) after the infusion of major histocompatability complex (MHC)-mismatched donor bone marrow cells given alone or in combination with an organ allograft.