Open AccessKidney graft failure and presensitization against HLA Class I and Class II antigens1
Author(s) -
Caner Süsal,
Gerhard Opelz
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200204270-00014
Subject(s) - human leukocyte antigen , medicine , antibody , kidney transplantation , kidney , immunology , kidney transplant , gastroenterology , antigen
It is well known that kidney transplant recipients with preformed lymphocytotoxic antibodies against HLA antigens have an increased graft rejection rate. However, the individual contribution of anti-HLA class I and class II antibodies to this phenomenon is poorly understood. We investigated the clinical relevance of preformed anti-HLA class I and class II antibodies on graft outcome in more than 4000 kidney recipients.