Open AccessRelationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients1
Author(s) -
R. Paul Robertson,
Karla J. Lanz,
David E.R. Sutherland,
Elizabeth R. Seaquist
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200203150-00013
Subject(s) - medicine , diabetes mellitus , contraindication , pancreas transplantation , insulin , insulin resistance , transplantation , glucose homeostasis , endocrinology , beta cell , obesity , hemoglobin , c peptide , homeostasis , pancreas , kidney transplantation , islet , pathology , alternative medicine
Healthy human volunteers occasionally elect to undergo surgical removal of the distal half of their pancreas for donation to a relative with type 1 diabetes. This provides the unusual opportunity to study segments of the same pancreas in two markedly different environments, i.e., the normal one of the donor and the unusual one of the ectopically transplanted recipient who is receiving immunosuppressant drugs that can diminish insulin secretion and cause insulin resistance.