Open AccessC1-inhibitor for prophylaxis of xenograft rejection after pig to cynomolgus monkey kidney transplantation
Author(s) -
Jens Hecker,
Ralf Lorenz,
Richard Appiah,
Burkhard Vangerow,
Martin Loss,
Robert F. Kunz,
Jan Schmidtko,
Michael Mengel,
Jürgen Klempnauer,
S. Piepenbrock,
Gerhard Dickneite,
Helge Neidhardt,
H. Rückoldt,
Michael Winkler
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200203150-00006
Subject(s) - xenotransplantation , medicine , kidney , kidney transplantation , transplantation , creatinine , cyclophosphamide , renal function , regimen , pharmacology , immunology , chemotherapy
Early rejection of discordant porcine xenografts in primate recipients is initiated by the intragraft binding of either preformed (hyperacute xenograft rejection) or induced (acute vascular rejection) antiporcine recipient antibodies with subsequent complement activation via the classical pathway. We have investigated the efficacy of the supplemental administration of C1-inhibitor (C1-INH), a specific inhibitor of the classical complement activation pathway, for prophylaxis of xenograft rejection in a pig to primate kidney xenotransplantation setting.