Open AccessPrevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance1
Author(s) -
Kazuhiro Yasufuku,
Kathleen M. Heidler,
Kena Woods,
Gerald N. Smith,
Oscar W. Cummings,
Takehiko Fujisawa,
David S. Wilkes
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200202270-00002
Subject(s) - bronchiolitis obliterans , antigen , immunology , medicine , immunosuppression , lung , lung transplantation , bronchiolitis , immune system , transplantation , immune tolerance , t lymphocyte , virus
We have reported that feeding type V collagen (col(V)) to lung allograft recipients induces immune tolerance that prevents acute lung allograft rejection. Repeated acute rejection is a risk factor for or associated with chronic rejection, known as bronchiolitis obliterans (BO), the leading cause of death in lung allograft recipients. The current study examines if col(V)-induced oral tolerance prevents BO.