Open AccessMIXED CHIMERISM OF THE RESIDENT MACROPHAGE POPULATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION FOR CHRONIC MYELOID LEUKEMIA1
Author(s) -
Claudia Wickenhauser,
Jüergen Thiele,
Fernando Guerrero Pérez,
E. Varus,
Marc Sebastian Stoffel,
Hans Michael Kvasnicka,
Dietrich W. Beelen,
U.W. Schaefer
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200201150-00020
Subject(s) - bone marrow , immunology , population , myeloid , biology , immunophenotyping , transplantation , myeloid leukemia , leukemia , macrophage , cd68 , medicine , pathology , antigen , immunohistochemistry , genetics , environmental health , in vitro
Bone marrow macrophages have been recognized to play a crucial role in the functional network that constitutes the microenvironment. In chronic myelogenous leukemia (CML), neoplastic macrophages are presumably responsible for the expansion of the leukemic cell clone. So far, no information is available about a persistence of host-type macrophages after allogeneic bone marrow transplantation (BMT) implicating a lineage-specific mixed chimerism.