Open AccessPIG HEMATOPOIETIC CELL CHIMERISM IN BABOONS CONDITIONED WITH A NONMYELOABLATIVE REGIMEN AND CD154 BLOCKADE1
Author(s) -
Léo Bühler,
Michel Awwad,
S. Treter,
Qing Chang,
M. Basker,
I. P. J. Alwayn,
Katsunori Teranishi,
Thomas Ericsson,
Kathleen Moran,
David R. Harper,
Barbara Kurilla-Mahon,
Christene A. Huang,
R. Sackstein,
Megan Sykes,
Mary E. WhiteScharf,
David H. Sachs,
Julian D. Down,
David K. C. Cooper
Publication year - 2002
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200201150-00004
Subject(s) - biology , immunosuppression , haematopoiesis , immunology , andrology , transplantation , monoclonal antibody , antibody , medicine , stem cell , genetics
In an attempt to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, we have infused high-dose porcine peripheral blood progenitor cells (PBPC) into baboons pretreated with a nonmyeloablative regimen and anti-CD154 monoclonal antibody (mAb).