Open AccessPHARMACOLOGICAL PRECONDITIONING WITH LOW-DOSE CYCLOSPORINE OR FK506 REDUCES SUBSEQUENT ISCHEMIA/REPERFUSION INJURY IN RAT KIDNEY1,2
Author(s) -
Chul Woo Yang,
Hyo Jun Ahn,
Hyuk Joon Han,
Wan Young Kim,
Can Li,
Mi Jung Shin,
Sung Kwon Kim,
Joo Hyun Park,
Yong Soo Kim,
In Sung Moon,
Byung Kee Bang
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200112150-00008
Subject(s) - tunel assay , dna laddering , medicine , pharmacology , apoptosis , reperfusion injury , ischemia , kidney , fas ligand , dna fragmentation , endocrinology , pathology , programmed cell death , biology , immunohistochemistry , biochemistry
Ischemia/reperfusion (I/R) injury in the early posttransplant period is closely associated with delayed recovery of graft function, increased acute rejection, and late allograft dysfunction. Pharmacological preconditioning with low-dose cyclosporine (CsA) or FK506 was performed to induce ischemic tolerance in rat kidney with I/R injury.