Open AccessDEPENDENCE OF MURINE OBSTRUCTIVE AIRWAY DISEASE ON CD40 LIGAND1
Author(s) -
Catherine A. Rumbley,
Scott J. Silver,
S M Phillips
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200111270-00007
Subject(s) - medicine , transplantation , cd40 , immunology , bronchiolitis , bronchiolitis obliterans , fibrosis , t cell , airway , cd28 , pathology , lung transplantation , biology , immune system , in vitro , virus , surgery , biochemistry , cytotoxic t cell
Human lung transplantation carries a poor prognosis because of chronic rejection in the form of obliterative bronchiolitis syndrome (OBS). Using the mouse model of heterotopic tracheal transplantation, we examined the role of costimulation in the allograft rejection that characterizes obstructive airway disease (OAD).