Open AccessMHC MATCHING AND MECHANISMS OF ALLOACTIVATION IN CORNEAL TRANSPLANTATION1
Author(s) -
Susan M. Nicholls,
Neil Williams
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200111150-00004
Subject(s) - major histocompatibility complex , immunology , mixed lymphocyte reaction , mhc class i , t cell , antigen , biology , human leukocyte antigen , transplantation , mhc class ii , medicine , immune system
In human corneal transplantation the value of matching, particularly for MHC class II, is unclear and controversial. The contribution of the direct pathway to T cell activation is also uncertain. We have determined the relative contribution of class I, II and non-MHC antigens to graft rejection and of the direct and indirect pathways to T cell activation in a rat model mimicking human incompatibilities.