Open AccessSHORT-TERM ???PRECONDITIONING??? WITH INHALED NITRIC OXIDE PROTECTS RABBIT LUNGS AGAINST ISCHEMIA-REPERFUSION INJURY1
Author(s) -
Hartwig Schütte,
Martin Witzenrath,
Konstantin Mayer,
Simone Rosseau,
Werner Seeger,
Friedrich Grimminger
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200110270-00005
Subject(s) - inhalation , nitric oxide , sodium nitroprusside , ischemia , medicine , anesthesia , pulmonary edema , vasodilation , pharmacology , reperfusion injury , ischemic preconditioning , edema , cyclic guanosine monophosphate , lung
Pulmonary edema, owing to an impairment of microvascular barrier function, is an important feature in lung ischemia/reperfusion (IR) injury. Inhalation of nitric oxide (NO) during the period of reperfusion has previously been shown to reduce this leakage response.