Open AccessTOLERANCE IN BABOON KIDNEY TRANSPLANTATION WITH TOTAL LYMPHOID IRRADIATION (TLI) AND ANTI-CD3/CD4-IDARUBICIN CONJUGATES1
Author(s) -
J. A. Myburgh,
J. A. Smit,
Geoffrey A. Pieterz,
Soong Ling,
Mauro S. Sandrin,
Ian F. C. McKenzie
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200109270-00028
Subject(s) - transplantation , baboon , medicine , idarubicin , kidney transplantation , immunosuppression , kidney , urology , surgery , chemotherapy , complete remission
We previously reported the induction of transplantation tolerance by a modified wide field method of pretransplant total lymphoid irradiation (TLI), cumulative dose 800 cGy, given as 80 or 100 cGy fractions twice/week, in approximately one-third of chacma baboons receiving liver or kidney allografts (1-4) and in vervet monkeys receiving baboon kidney xenografts (5). In this study, the effects of the administration of brief courses of anti-CD3 or CD4-Idarubicin conjugates on the frequency and predictability of tolerance induction by TLI were examined.