Open AccessABSORPTION PROFILING OF CYCLOSPORINE MICROEMULSION (NEORAL) DURING THE FIRST 2 WEEKS AFTER RENAL TRANSPLANTATION1
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200109270-00008
Subject(s) - medicine , immunosuppression , pharmacokinetics , confidence interval , urology , transplantation , area under the curve , kidney transplantation , adverse effect , ciclosporin , cmax , gastroenterology , surgery
Evidence suggests that optimal immunosuppressive drug exposure must be achieved early posttransplant to minimize the risk of acute graft rejection. This study was designed to examine the absorption profile of Neoral during the first 2 weeks after renal transplantation, to develop simple sparse-sampling pharmacokinetic methods to predict exposure, and to explore the target range for optimal clinical immunosuppression under conditions of normal clinical practice.