Open AccessDONOR AND RECIPIENT PRETRANSPLANT CONDITIONING WITH NONLETHAL RADIATION AND ANTILYMPHOCYTE SERUM IMPROVES THE GRAFT SURVIVAL IN A RAT SMALL BOWEL TRANSPLANT MODEL1,2
Author(s) -
Alexandre Bakonyi,
Mariana Berho,
Phillip Ruiz,
Evangelos P. Misiakos,
Manuel Carreño,
Werviston De Faria,
Antonio Sommariva,
Luca Inverardi,
Joshua Miller,
Camillo Ricordi,
Andreas G. Tzakis
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200109270-00001
Subject(s) - medicine , tacrolimus , total body irradiation , incidence (geometry) , graft versus host disease , transplantation , gastroenterology , bone marrow , lymphocyte subsets , immunology , urology , immune system , t cell , chemotherapy , physics , optics , cyclophosphamide
Lymphoid tissue within the intestinal graft require immunomodulatory strategies to prevent graft versus host disease (GVHD) after transplant. Herein, we evaluate the potential advantage of donor-specific bone marrow infusions in donor and or recipient preconditioned with total body irradiation and or antilymphocyte serum (ALS) on the incidence of GVHD and rejection after small bowel transplantation.