Open AccessCYTOTOXIC T-LYMPHOCYTE ANTIGEN 4 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO ACUTE ALLOGRAFT REJECTION1
Author(s) -
E Slavcheva,
Efsevia Albanis,
Qingsheng Jiao,
Hoanh Tran,
Carol Bodian,
Richard J. Knight,
Edgar L. Milford,
Thomas D. Schiano,
Yaron Tomer,
Barbara Murphy
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200109150-00032
Subject(s) - allele , immunology , single nucleotide polymorphism , medicine , cytotoxic t cell , gene polymorphism , genotype , gastroenterology , biology , gene , genetics , in vitro
Cytotoxic T-lymphocyte antigen 4 (CTLA4) has been shown to play a critical role in the down-regulation of the immune response. We retrospectively examined the association between acute rejection and two polymorphisms in the CTLA4 gene, the dinucleotide (AT)n repeat polymorphism in exon 3 and the single nucleotide polymorphism A/G at position 49 in exon 1, in a cohort of liver and kidney transplant recipients.