Open AccessHLA-C MISMATCHES INDUCE STRONG CYTOTOXIC T-CELL REACTIVITY IN THE PRESENCE OF AN ADDITIONAL DRB/DQB MISMATCH AND AFFECT NK CELL???MEDIATED ALLOREACTIVITY
Author(s) -
Arnold van der Meer,
Wil A. Allebes,
Jos Paardekooper,
J. P. N. Ruiter,
Irma Joosten
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200109150-00030
Subject(s) - epitope , human leukocyte antigen , cytotoxic t cell , immunology , antigen , major histocompatibility complex , immunogenicity , hla c , biology , in vitro , genetics
The functional relevance of HLA-C mismatches in an alloresponse is still much debated, putting into doubt the relevance of matching for this antigen in selection of an allogeneic bone marrow donor. In addition to presenting peptides to T cells, HLA-C also functions as a ligand for killing inhibitory receptors (KIRs) on natural killer (NK) cells. In the current study we provide an in vitro basis to address the question of whether mismatches for this antigen are a risk factor for acute graft-versus-host disease (GVHD).