Open AccessTNF-??, IL-6, IFN-??, AND IL-10 GENE EXPRESSION POLYMORPHISMS AND THE IL-4 RECEPTOR ??-CHAIN VARIANT Q576R: EFFECTS ON RENAL ALLOGRAFT OUTCOME
Author(s) -
Amy B. Hahn,
Jane KastenJolly,
Don Constantino,
Eileen Graffunder,
Tejinder P. Singh,
Gary K. Shen,
David Conti
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200108270-00017
Subject(s) - immunology , cytokine , tumor necrosis factor alpha , human leukocyte antigen , interleukin 10 , proinflammatory cytokine , alpha chain , biology , major histocompatibility complex , cytokine receptor , interferon gamma , receptor , medicine , antigen , inflammation , genetics
There has been much interest recently in the effects of various cytokine gene expression polymorphisms on graft outcome. However, the results of these investigations reveal the outcomes to be organ-specific and center-specific. We sought to confirm and add to some of the earlier findings by studying the impact of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), interferon-gamma (IFN-gamma), and interleukin-6 (IL-6) polymorphisms and the interleukin-4 (IL-4) receptor alpha-chain variant on posttransplant renal allograft outcome.