Open AccessCOMPARISON OF ACTIVATION REQUIREMENTS AND ACTIVATION PHENOTYPE OF ALLOGENEIC AND XENOGENEIC RODENT RESPONSES IN VIVO AND IN VITRO1
Author(s) -
Jose Trani,
Howard K. Song,
Susan Lerner,
Joseph W. Markmann,
Clyde F. Barker,
Ali Naji,
James F. Markmann
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200108150-00021
Subject(s) - in vivo , immunology , biology , microbiology and biotechnology , cd8 , immune system , in vitro , t cell , genetics
Both discordant and concordant xenogeneic responses are dominated by humoral immunity. Recent advances in molecular engineering approaches may largely prevent rejection by means of this pathway, leaving the cellular arm of the immune response as the principal remaining barrier to successful engraftment.