Open AccessINTERLEUKIN-17 ANTAGONISM INHIBITS ACUTE BUT NOT CHRONIC VASCULAR REJECTION1
Author(s) -
J.L Tang,
Владимир Субботин,
Mary A. Antonysamy,
Anthony B. Troutt,
Abdul S. Rao,
Angus W. Thomson
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200107270-00035
Subject(s) - mononuclear cell infiltration , medicine , peripheral blood mononuclear cell , aorta , endothelium , pathology , immunology , chemistry , endocrinology , biochemistry , in vitro
Blocking the action of interleukin (IL) 17 with an IL-17 receptor (R):Fc fusion protein inhibits T-cell proliferative responses to alloantigens and prolongs vascularized heart graft survival. In this study, we examined whether IL-17 antagonism could suppress the development of chronic rejection.