Open AccessTREATMENT OF CHRONIC RENAL ALLOGRAFT REJECTION IN RATS WITH A LOW-MOLECULAR-WEIGHT HEPARIN (REVIPARIN)
Author(s) -
Claude Braun,
Melanie Schultz,
Fang Liu,
Michael T. Schaub,
Walter Back,
Dieter Herr,
Volker Laux,
Peter Rohmeiss,
Peter Schnuelle,
Fokko J. van der Woude
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200107270-00007
Subject(s) - medicine , urology , transplantation , immunohistochemistry , kidney disease , nephrectomy , kidney , pathology , gastroenterology
Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study was to determine whether treatment with the LMWH reviparin has a beneficial effect on chronic rejection in a rat renal allograft model.