Open AccessMECHANISMS OF THROMBOTIC MICROANGIOPATHY FOLLOWING XENOGENEIC HEMATOPOIETIC PROGENITOR CELL TRANSPLANTATION1
Author(s) -
Ian Alwayn,
Léo Bühler,
James Z. Appel,
Christian Goepfert,
Eva Csizmadia,
L Correa,
David R. Harper,
Hiroshi Kitamura,
Julian D. Down,
Michel Awwad,
Robert Sackstein,
D. K. C. Cooper,
Simon C. Robson
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200106150-00020
Subject(s) - baboon , platelet , thrombotic microangiopathy , andrology , haematopoiesis , progenitor cell , xenotransplantation , immunology , in vivo , medicine , pathology , transplantation , biology , stem cell , microbiology and biotechnology , disease
Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops immediately after the infusion of porcine mobilized peripheral blood leukocytes, containing progenitor cells (PBPC). In our study, we examined the interaction of infused porcine PBPC with recipient platelets in vivo in baboons and investigated the underlying mechanisms using an in vitro model.