Open AccessT CELL AND B CELL TOLERANCE TO GAL??1,3GAL-EXPRESSING HEART XENOGRAFTS IS ACHIEVED IN ??1,3-GALACTOSYLTRANSFERASE-DEFICIENT MICE BY NONMYELOABLATIVE INDUCTION OF MIXED CHIMERISM1
Author(s) -
Hideki Ohdan,
YongGuang Yang,
Kirsten G. Swenson,
Hiroshi Kitamura,
Megan Sykes
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200106150-00009
Subject(s) - immunology , haematopoiesis , bone marrow , b cell , biology , transplantation , receptor , cell , transplantation chimera , antibody , chimera (genetics) , immune tolerance , total body irradiation , stem cell , immune system , medicine , cyclophosphamide , hematopoietic cell , microbiology and biotechnology , chemotherapy , biochemistry , genetics , gene
We have previously demonstrated that mixed xenogeneic chimerism and donor-specific T-cell tolerance can be induced in the rat-to-mouse species combination by using a relatively nontoxic, nonmyeloablative conditioning regimen. However, natural antibodies (NAbs) against Galalpha1,3Gal (Gal) pose an additional major barrier to pig-to-human vascularized xenograft acceptance.