Open AccessINDUCTION OF TRANSPLANTATION TOLERANCE WITH A SHORT COURSE OF TACROLIMUS(FK506)
Author(s) -
Ryu Utsugi,
Rolf N. Barth,
Richard S. Lee,
Hiroshi Kitamura,
John C. LaMattina,
Joseph Ambroz,
David H. Sachs,
Kazuhiko Yamada
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200105270-00003
Subject(s) - tacrolimus , medicine , immunosuppression , transplantation , immunology , major histocompatibility complex , immune system
Inbred miniature swine provide a large animal model in which the effects of selective major histocompatibility complex (MHC) matching can be reproducibly studied. We have previously demonstrated that although a 12-day course of cyclosporine uniformly induces tolerance to class I-mismatched renal allografts, it does not induce tolerance across full MHC barriers. In this study, we assessed whether and at what dose tacrolimus might permit allografts to induce tolerance across different MHC barriers.